Strategies for informed sample size reduction in adaptive controlled clinical trials
نویسندگان
چکیده
منابع مشابه
Strategies for informed sample size reduction in adaptive controlled clinical trials
Clinical trial adaptation refers to any adjustment of the trial protocol after the onset of the trial. The main goal is to make the process of introducing new medical interventions to patients more efficient. The principal challenge, which is an outstanding research problem, is to be found in the question of how adaptation should be performed so as to minimize the chance of distorting the outco...
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An outcome variable is one which we hope to change, predict or estimate in a trial. Examples: • Systolic blood pressure in a hypertension trial • Caesarean section rate in an obstetric trial • Survival time in a cancer trial How many outcome variables should I have? If we have many outcome variables: • all possibilities would be covered, • we would be less likely to miss something, • the risk o...
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Most informed consent documents for randomized controlled trials implicitly or explicitly promise the prospective participant that the trial has a reasonable chance of answering a medically important question. The medical literature, however, is replete with descriptions of trials that provided equivocal answers to the questions they addressed. Papers describing the results of such studies may ...
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ژورنال
عنوان ژورنال: EURASIP Journal on Advances in Signal Processing
سال: 2017
ISSN: 1687-6180
DOI: 10.1186/s13634-017-0510-z